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Publications

  1. Belelovsky K, Elkobi A, Kaphzan H, Nairn AC, Rosenblum K (2005) A molecular switch for translational control in taste memory. European Journal of Neuroscience, 22:2560-8.

  2. Kaphzan H, O'Riordan K J, Mangan KP, Levenson JM, Rosenblum K (2006) NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus. PLoS ONE, 1:e138.

  3. Kaphzan H, Doron G, Rosenblum K (2007) Co-application of NMDA and dopamine-induced rapid translation of RSK2 in the mature hippocampus. Journal of Neurochemistry, 103: 388–399.  

  4. Belelovsky K, Kaphzan H, Elkobi A, Rosenblum K (2009) Biphasic activation of the mTOR pathway in the gustatory cortex is correlated and necessary for taste learning. Journal of Neuroscience, 29: 7424-7431.

  5. Kaphzan H, Buffington SA, Jung JI, Rasband MN, Klann E (2011) Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. Journal of Neuroscience, 31: 17637-17648.

  6. Chevere I, Kaphzan H, Bhattacharya A, Kang A, Maki JM, Gambello JM, Santini E, Arbiser JL, Klann E (2012) Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG model of tuberous sclerosis complex. Neurobiology of Disease, 45: 1101-1110.

  7. Kaphzan H, Hernandez P, Jung JI, Cowansage KK, Deinhardt K, Chao MV, Abel T, Klann E (2012) Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors. Biological Psychiatry, 72:182-90.

  8. Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E (2012) Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility. Cell Reports, 1: 676-88.

  9. Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A (2012) Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Molecular Neurodegeneration, 7: 48-66.

  10. Bhattacharya A, Kaphzan H, Alvarez-Dieppa AC, Murphy JP, Pierre P, Klann E (2012) Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice. Neuron, 76: 325-37.

  11. Santini E, Huynh TN, MacAskill AF, Carter AG, Ruggero D, Pierre P, Kaphzan H, Klann E (2013) Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature, 493: 411-5.

  12. Kaphzan H, Buffington SA, Ramaraj AB, Lingrel JB, Rasband MN, Santini E, Klann E (2013) Genetic Reduction of the α1 Subunit of Na/K-ATPase Corrects Multiple Hippocampal Phenotypes in Angelman Syndrome. Cell Reports, 4: 405-12.

  13. Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM,  Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Akbarian S, Chattarji S, Klann E, Richter JD (2013) Genetic and acute CPEB1 Depletion Ameliorates Fragile X Pathophysiology. Nature Medicine, 19: 1473-7.

  14. Kaphzan H, Ben-Shachar D, Klein E (2014) Entacapone augmentation of antipsychotic treatment in schizophrenic patients; a double blind placebo controlled study. International Journal of Neuropsychopharmacology, 17:337-40.

  15. Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E (2014) The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learning & Memory, 21:298-304.

  16. David O, Barrera I, Chinnakkaruppan A, Kaphzan H, Nakazawa T, Yamamoto T, Rosenblum K (2014) Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information. Frontiers in Molecular Neuroscience, 7:66.

  17. Santini E, Turner KL, Ramaraj AB, Murphy MP, Klann E, Kaphzan H (2015) Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice. Journal of Neuroscience 35:16213-20

  18. Sethna F, Zhang M, Kaphzan H, Klann E, Autio D, Cox CL, Wang H (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. Journal of Neuroscience Research 94:401-8

  19. Sams DS, Nardone S, Getselter D, Raz D, Tal M, Rayi PR, Kaphzan H, Hakim O, Elliott E (2016) Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc. Cell Reports 17:2418–2430

  20. Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G (2017) GABAergic synapses at the axon initial segment of basolateral amygdala projection neurons modulate fear extinction.  Neuropsychopharmacology 42:473-484

  21. Chakraborty D, Bagrov AY, Fedorova OV, Kaphzan H (2017) Selective ligands for Na+/K+-ATPase alpha-isoforms differentially and cooperatively regulate excitability of pyramidal neurons in distinct brain regions. Neuropharmacology 117:338-351

  22. Sharma V, Ounallah-Saad H, Chakraborty D, Hleihil M, Sood R, Barrera I, Edry E, Kolatt Chandran S, Ben Tabou de Leon S, Kaphzan H, Rosenblum K. (2018) Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties. Journal of Neuroscience 38:648-658

  23. Chakraborty D, Truong D, Bikson M, Kaphzan H (2018) Neuromodulation of axon terminals. Cerebral Cortex 28:2786-2794

  24. Lander SS, Khan U, Lewandowski N, Chakraborty D, Provenzano FA, Mingote S, Chornyy S, Frigerio F, Maechler P, Kaphzan H, Small SA, Rayport S, Gaisler-Salomon I. (2019) Glutamate dehydrogenase-deficient mice display schizophrenia-like behavioral abnormalities and CA1-specific hippocampal dysfunction. Schizophrenia Bulletin 45:127-137

  25. Koyavski L, Panov J, Simchi L, Rayi PR, Sharvit L, Feuermann Y, Kaphzan H. (2019) Sex-dependent sensory phenotypes and related transcriptomic expression profiles are differentially affected by Angelman syndrome. Molecular Neurobiology 56:5998-6016

  26. Rayi PR, Koyavski L, Chakraborty D, Bagrov AY, Kaphzan H. (2019) α1-Na/K-ATPase inhibition rescues aberrant dendritic calcium dynamics and memory deficits in the hippocampus of an Angelman syndrome mouse model. Progress in Neurobiology 182:101676

  27. Simchi L, Panov J, Morsey O, Feuerman Y, Kaphzan H (2020) Novel insights into the role of UBE3A in apoptosis and proliferation. Journal of Clinical Medicine 9:1573.

  28. Panov J, Simchi L, Feuerman Y, Kaphzan H (2020) Bioinformatics analyses of the transcriptome reveal Ube3a-dependent effects on mitochondrial-related pathways. International Journal of Molecular Sciences 21:4156.

  29. Rayi PR, Bagrov AY, Kaphzan H (2021) Chronic a1-Na/K-ATPase inhibition reverses the elongation of the axon initial segment of the hippocampal CA1 pyramidal neurons in Angelman syndrome model mice. Neuropsychopharmacology 6:654-664. 

  30. Panov J, Kaphzan H (2021) Bioinformatics analyses show dysregulation of calcium-related genes in Angelman syndrome mouse model. Neurobiology of Disease 148:105180.

  31. Simchi L, Kaphzan H (2021) Aberrant aggressive behavior in a mouse model of Angelman syndrome. Scientific Reports 11:47. doi: 10.1038/s41598-020-79984-7

  32. Rayi PR, Kaphzan H (2021) Electrophysiological characterization of regular and burst firing pyramidal neurons of the dorsal subiculum in an Angelman syndrome mouse model. Frontiers in Cellular Neuroscience https://doi.org/10.3389/fncel.2021.670998

  33. Panov J, Kaphzan H (2021) Angelman syndrome and Angelman-like syndromes share the same calcium-related gene signatures. International Journal of Molecular Sciences 22(18):9870.

  34. Vasu SO, Kaphzan H (2021) The Role of sodium channels in direct current stimulation - axonal perspective.  Cell Reports 37:109832.

  35. Magal T, Negev M, Kaphzan H (2021) Attitudinal barriers hindering adoption of telepsychiatry among mental healthcare professionals: Israel as a Case-Study. International Journal of Environmental Research and Public Health 18:12540.

  36. Vasu SO, Kaphzan H (2022) Calcium channels control tDCS-induced spontaneous vesicle release from axon terminals. Brain stimulation 15:270-282.

  37. Kaphzan H, Sarfati-Noiman M, Negev M (2022) The attitudes and perceptions of psychiatrists in Israel towards telepsychiatry and their behavioral intention to use telepsychiatry. Frontiers in Psychiatry 13:829965. doi: 10.3389/fpsyt.2022.829965.

  38. Davis L, Rayi PR, Getselter D, Kaphzan H, Elliott E (2022) CTCF in parvalbumin-expressing neurons regulates motor, anxiety and social behavior and neuronal identity. Molecular Brain 15(1):30. doi: 10.1186/s13041-022-00916-9.

  39. Vasu SO, Kaphzan H (2022) The role of axonal voltage-gated potassium channels in tDCS. Brain stimulation 15:861-869. doi:10.1016/j.brs.2022.05.019.

  40. Rathour RK, Kaphzan H (2022) Voltage-gated ion channels and the variability in information transfer. Frontiers in Cellular Neuroscience 16:906313. doi: 10.3389/fncel.2022.906313

  41. Panov J, Kaphzan H (2022) An association study of DNA methylation and gene expression in Angelman syndrome: a bioinformatics approach. International Journal of Molecular Sciences 23:9139. doi: 10.3390/ijms23169139

  42. Simchi L, Gupta KR, Feuermann Y, Kaphzan H (2023) Elevated ROS levels during the early development of Angelman syndrome alter the apoptotic capacity of the developing neural precursor cells.  Molecular Psychiatry (epub ahead of print). doi: 10.1038/s41380-023-02038-7

  43. Rathour RK, Kaphzan H (2023) Synergies between synaptic and HCN channel plasticity dictates firing rate homeostasis and mutual information transfer in hippocampal model neuron. Frontiers in Cellular Neuroscience 17:1096823 doi: 10.3389/fncel.2023.1096823

  44. Negev M, Magal T, Kaphzan H (2023) Attitudes of psychiatrists toward telepsychiatry: A policy Delphi study. Digital Health 9:20552076231177132. doi: 10.1177/20552076231177132

  45. Vasu SO, Kaphzan H (2023) Direct current stimulation modulates synaptic facilitation via distinct presynaptic calcium channels. International Journal of Molecular Sciences (in press).

 

 

Articles in Conference Proceedings Published 

 

1. Klann E, Bhattacharia A, Kaphzan H, Santini E, Wong MA. (2011) Translation dysregulation in autism spectrum disorders. Journal of Neurochemistry 118:14

2.  Rosenblum K, Belelovsky K, Kaphzan H, Elkobi A (2011) Biphasic activation of the mTOR pathway in the cortex. Journal of Neurochemistry 118:86

3. Saha R, Chakraborty D#, Knapp S, Schayek R, Shrivasta K, Kaphzan H, Ehrlich I, Maroun M, Kriebel M, Volkmer H, Richter-Levin G (2017) Compartmentalised perturbation of GABAergic synapses in the basolateral amygdala principal neurons. European Neuropsychopharmacology 27:539

4. Lander SS, Chakraborty D#, Donner R, Provenzano F, Lewandowski N, Mingote SM, Maechler P, Rayport S, Small SA, Kaphzan H, Gaisler-Salomon I (2017) Glutamate dehydrogenase deficient mice: a novel mouse model of schizophrenia-like phenotypes. Schizophrenia Bulletin 43:109-110

5. Gaisler-Salomon I, Lander SS, Chakraborty D#, Asraf K, Safory H, Wolosker H, Kaphzan H (2019) Neuronal-astrocytic regulation of glutamate homeostasis: relevance to cognitive dysfunction in schizophrenia Schizophrenia Bulletin 45:124

6. Vasu SO#, Kaphzan H. (2019)  NYC Neuromodulation 2018 Proceedings #28: A model for tDCS-induced spontaneous vesicle release.  Brain Stimulation 12: e161–e163. 

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Patents

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*US Patent Application No. 16/975,129;  2021

Methods for treating memory impairment and cognitive dysfunction 

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