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Publications

List of Publications 

  1. Belelovsky K, Elkobi A, Kaphzan H, Nairn AC, Rosenblum K (2005) A molecular switch for translational control in taste memory. European Journal of Neuroscience, 22:560-8.

  2. Kaphzan H, O'Riordan K J, Mangan KP, Levenson JM, Rosenblum K (2006) NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus. PLoS ONE, 1:e138.    

  3. Kaphzan H, Doron G, Rosenblum K (2007) Co-application of NMDA and dopamine-induced rapid translation of RSK2 in the mature hippocampus. Journal of Neurochemistry, 103: 388–399.  

  4. Belelovsky K, Kaphzan H, Elkobi A, Rosenblum K (2009) Biphasic activation of the mTOR pathway in the gustatory cortex is correlated and necessary for taste learning. Journal of Neuroscience, 29: 7424-7431.  

  5. Kaphzan H, Buffington SA, Jung JI, Rasband MN, Klann E (2011) Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. Journal of Neuroscience, 31: 17637-17648.

  6. Chevere I, Kaphzan H, Bhattacharya A, Kang A, Maki JM, Gambello JM, Santini E, Arbiser JL, Klann E (2012) Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG model of tuberous sclerosis complex. Neurobiology of Disease, 45: 1101-1110.

  7. Kaphzan H, Hernandez P, Jung JI, Cowansage KK, Deinhardt K, Chao MV, Abel T, Klann E (2012) Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors. Biological Psychiatry, 72:182-90.

  8. Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E (2012) Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility. Cell Reports, 1: 676-88.

  9. Keiichi I, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A (2012) Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Molecular Neurodegeneration, 7: 48-66.

  10. Bhattacharya A, Kaphzan H, Alvarez-Dieppa AC, Murphy JP, Pierre P, Klann E (2012) Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice. Neuron, 76: 325-37.

  11. Santini E, Huynh TN, MacAskill AF, Carter AG, Ruggero D, Pierre P, Kaphzan H, Klann E (2013) Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature, 493: 411-5.

  12. Kaphzan H, Buffington SA, Ramaraj AB, Lingrel JB, Rasband MN, Santini E, Klann E (2013) Genetic Reduction of the α1 Subunit of Na/K-ATPase Corrects Multiple Hippocampal Phenotypes in Angelman Syndrome. Cell Reports, 4: 405-12.

  13. Udagawa T#, Farny NG#, Jakovcevski M#, Kaphzan H, Alarcon JM,  Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Akbarian S, Chattarji S, Klann E, Richter JD (2013) Genetic and acute CPEB1 Depletion Ameliorates Fragile X Pathophysiology. Nature Medicine, 19: 1473-7.

  14. Kaphzan H, Ben-Shachar D, Klein E (2014) Entacapone augmentation of antipsychotic treatment in schizophrenic patients; a double blind placebo controlled study. International Journal of Neuropsychopharmacology, 17:337-40.

  15. Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E (2014) The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learning & Memory, 21:298-304.

  16. David O, Barrera I, Chinnakkaruppan A, Kaphzan H, Nakazawa T, Yamamoto T, Rosenblum K (2014) Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information. Frontiers in Molecular Neuroscience, 7:66.

  17. Santini E, Turner KL, Ramaraj AB, Murphy MP, Klann E, Kaphzan H (2015) Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice. Journal of Neuroscience 35:16213-20

  18. Sethna F, Zhang M, Kaphzan H, Klann E, Autio D, Cox CL, Wang H (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. Journal of Neuroscience Research 94:401-8

  19. Sams DS, Nardone S, Getselter D, Raz D, Tal M, Rayi PR, Kaphzan H, Hakim O, Elliott E (2016) Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc. Cell Reports 17:2418–2430 

  20. Saha R, Knapp S, Chakraborty D, Horovitz O, Albrecht A, Kriebel M, Kaphzan H, Ehrlich I, Volkmer H, Richter-Levin G (2017) GABAergic synapses at the axon initial segment of basolateral amygdala projection neurons modulate fear extinction.  Neuropsychopharmacology 42:473-484

  21. Chakraborti D, Bagrov AY, Fedorova OV, Kaphzan H (2017) Selective ligands for Na+/K+-ATPase alpha-isoforms differentially and cooperatively regulate excitability of pyramidal neurons in distinct brain regions. Neuropharmacology 117:338-351  

  22. Sharma V, Ounallah-Saad H, Chakraborty D, Hleihil M, Sood R, Barrera I, Edry E, Kolatt Chandran S, Ben Tabou de Leon S, Kaphzan H, Rosenblum K. (2018) Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties. Journal of Neuroscience 35:16213-20

  23. Chakraborti D, Truong D, Bikson M, Kaphzan H (2018) Neuromodulation of axon terminals. Cerebral Cortex 28:2786-2794 

  24. Lander SS, Khan U, Lewandowski N, Chakraborty D, Provenzano FA, Mingote S, Chornyy S, Frigerio F, Maechler P, Kaphzan H, Small SA, Rayport S, Gaisler-Salomon I. (2019) Glutamate dehydrogenase-deficient mice display schizophrenia-like behavioral abnormalities and CA1-specific hippocampal dysfunction. Schizophrenia Bulletin 45:127-137

  25. Koyavski L, Panov J, Simchi L, Rayi PR, Sharvit L, Feuermann Y, Kaphzan H. (2019) Sex-dependent sensory phenotypes and related transcriptomic expression profiles are differentially affected by Angelman syndrome. Molecular Neurobiology doi: 10.1007/s12035-019-1503-8.

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